If half of the two hundred women in our tribe have sons, and only sons, then one hundred mitochondrial lineages will dash against the glass pane of male-only heredity and vanish in the next generation. The Gene: An Intimate History. And here is the crux: if the founding population of a species is small enough, and if enough time has passed, the number of surviving maternal lineages will keep shrinking, and shrinking further, until only a few are left. /I/ Genes can certainly tell us about race, but can race tell us anything about genes? But the vastly more controversial question is the converse: Given a racial identity -- African or Asian, say -- can you infer anything about an individual's characteristics: not just skin or hair color, but more complex features, such as intelligence, habits, personality, and aptitude? The”, “Modesty is a virtue,” he would later write, “yet one gets further without it.”, “Organisms exist not because of reactions that are possible, but because of reactions that are barely possible.”, “The crucial driver of evolution, Darwin understood, was not nature’s sense of purpose, but her sense of humor).”, “If you know the question, you know half.”, “that the largest “negative eugenics” project in human history was not the systemic extermination of Jews in Nazi Germany or Austria in the 1930s. But if she has only a son and no daughter, the woman’s mitochondrial lineage wanders into a genetic blind alley and becomes extinct (since sperm do not pass their mitochondria to the embryo, sons cannot pass their mitochondrial genomes to their children). Chance would become mitigated, but so, inevitably, would choice.”, “Genetic tests,” as Eric Topol, the medical geneticist described it, “are also moral tests. These mitochondria are the energy-producing factories of the cell; they are so anatomically discrete and so specialized in their function that cell biologists call them “organelles”—i.e., mini-organs resident within cells. We slow down reactions, concentrate matter, and organize chemicals into compartments; we sort laundry on Wednesdays. This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. Hide other formats and editions. If we define "intelligence" as the performance on only one kind of test, then we will, indeed, find a "gene for intelligence." The 2011 Pulitzer Prize winner, Siddhartha Mukherjee, is back with another incredibly well-written book, The Gene: An Intimate History that unfolds the extensive and profound knowledge and research about human genome and its genetics that reflects beyond the definition of both basic and advanced science. Surgical interventions were reserved to correct specific deformities as they arose. Please help improve this article by adding quotes to reliable sources. This is an epic, moving history of a scientific idea being brought to life, by the author of The Emperor of All Maladies. Author Midnight Knitter Posted on July 4, 2016 Categories Books, Gardening Tags auxin, Books, Charles Darwin, DNA, evolution, gardening, genes, roses, Siddharthe Mukherjee, The Gene: An Intimate History, white squirrel 7 Comments on Darwin’s Garden The Gene: An Intimate History THE GENE: An Intimate History, Siddhartha Mukherjee’s follow-up to the bestselling, Pulitzer-winning The Emperor of All Maladies , is the story of the quest to decipher the master-code of instructions that makes and defines humans, that governs our form, function, and fate and determines the future of our children. New York: Scribner. New from. Let us know what’s wrong with this preview of, Published From Mendel growing his peas via Darwin and the origin of species, eugenics and the Nazis, Crick and Watson discovering the double helix structure of DNA to the tantalising prospects of genome enhancement, Siddhartha Mukherjee takes us comprehensively … Monster by monster, evolution advanced”. "It sometimes seems as if curbing entropy is our quixotic purpose in the universe," James Gleick wrote. Life is designed to combat these forces. This is an epic, moving history … We call one such unique variant of one such organism a "self.”. An upright organism with opposable thumbs is thus built from a script, but built to go off script. ― Siddhartha Mukherjee, The Gene: An Intimate History. “It is a testament to the unsettling beauty of the genome that it can make the real world "stick". The Gene: An Intimate History. "Sid Mukherjee has the uncanny ability to bring … First Scribner hardcover edition. ** NEW YORK TIMES NUMBER ONE BESTSELLER **. just now. The gene an intimate history Mukherjee , Siddhartha From the Pulitzer Prize-winning, bestselling author of The Emperor of All Maladies —a magnificent history of the gene and a response to the defining question of the future: What becomes of being human when we learn to … Nice primer to the work, which will take a lot of time to read so I'll probably read it is sections and rest with fluff reading in between. The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. Avery”, “Seek simplicity, but distrust it,” Alfred North Whitehead, the mathematician and philosopher, once advised his students. Free download or read online The Gene: An Intimate History pdf (ePUB) book. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. Be the first to ask a question about Summary and Analysis of The Gene. The first edition of the novel was published in May 17th 2016, and was written by Siddhartha Mukherjee. You can scan any individual genome and infer rather deep insights about a person's ancestry, or place of origin. New York: Scribner. [1] The book chronicles the history of the gene and genetic research, all the way from Aristotle to Crick , Watson and Franklin and then the 21st century scientists who mapped the human genome . I find the idea of such a founding mother endlessly mesmerizing. The parables of such scientific overreach are well-known: foreign animals, introduced to control pests, become pests in their own right; the raising of smokestacks, meant to alleviate urban pollution, releases particulate effluents higher in the air and exacerbates pollution; stimulating blood formation, meant to prevent heart attacks, thickens the blood and results in an increased risk of blood clots in the heart. The gene: an intimate history. Goodreads helps you keep track of books you want to read. Monster by monster, evolution advanced”, “Normalcy is the antithesis of evolution.”, “If we define "beauty" as having blue eyes (and only blue eyes), then we will, indeed, find a "gene for beauty." Preview — The Gene by Siddhartha Mukherjee. The Gene: An Intimate History interweaves an account of the thrilling revolution in modern genetic science with powerful stories from the frontlines of medicine. The story of the gene begins …. From Mendel growing his peas via Darwin and the origin of species, eugenics and the Nazis, Crick and Watson discovering the double helix structure of DNA to the tantalising prospects of genome enhancement, Siddhartha Mukherjee takes us comprehensively through the whole history. All Quotes Over the course of the tribe’s evolution, tens of thousands of such mitochondrial lineages will land on lineal dead ends by chance, and be snuffed out. But it could just as easily be a network of genes.”, “It is not what you have,” as a certain Brazilian samba instructor once told me, “it is what you do with it.”, “Natures and features last until the grave”, “It is one thing to try to understand how genes influence human identity or sexuality or temperament. For modern humans, that number has reached one: each of us can trace our mitochondrial lineage to a single human female who existed in Africa about two hundred thousand years ago. The Gene: An Intimate History. It features patients suffering from rare genetic diseases and the leading researchers racing to identify and treat - or even cure - the errors in their DNA that afflict them. There are no discussion topics on this book yet. Just a moment while we sign you in to your Goodreads account. This book is not yet featured on Listopia. It is a question that requires us to balance the desires of the individual— to carve out a life of happiness and achievement, without undue suffering— with the desires of a society that, in the short term, may be interested only in driving down the burden of disease and the expense of disability. The Gene: An Intimate History Hardcover – Illustrated, May 17 2016. We live in the loopholes of natural laws, seeking extensions, exceptions and excuses. “When scientists underestimate complexity, they fall prey to the perils of unintended consequences. See all formats and editions. Mukherjee, Siddhartha. The Gene: An Intimate History by Siddhartha Mukherjee The Gene is the story of one of the most powerful and dangerous ideas in our history, from bestselling, prize-winning author Siddhartha Mukherjee. Refresh and try again. She is the common mother of our species. Genes must carry out programmed responses to environments - otherwise, there would be no conserved form. It was published on 17 May 2016 by Scribner . 2016. Traumas might be erased but so might history. That is a question of biological systematics -- of lineage, taxonomy, of racial geography, of biological discrimination. The Gene: An Intimate History 4.34 avg rating — 35,423 ratings — published 2016 — 74 editions Want to Read saving… And operating silently in the background is a third set of actors: our genes themselves, which reproduce and create new variants oblivious of our desires and compulsions— but, either directly or indirectly, acutely or obliquely, influence our desires and compulsions. Of course you can -- and genomics as vastly refined that inference. It isn’t creativity that fades, but stamina: science is an endurance sport. This self-fulfilling circle of logic is responsible for some of the most magnificent and evocative qualities in our species, but also some of the most reprehensible. Scribner, 2017. The Gene: An Intimate History is a book written by Siddhartha Mukherjee, an Indian-born American physician and oncologist. We call this intersection "fate". We’d love your help. S iddhartha Mukherjee calls his history of genetics “intimate” for two reasons. (A woman also carries the mitochondrial genomes of all her future descendants in her cells; ironically, if there is such a thing as a “homunculus,” then it is exclusively female in origin—technically, a “femunculus”?) With David Costabile, Edward Wild. Part 1 of 2. 27,659 Ratings. In human genetics, she is known by a beautiful name—Mitochondrial Eve.”, “Cancer, perhaps, is an ultimate perversion of genetics—a genome that becomes pathologically obsessed with replicating itself. We call our responses to it "choice". These concerns reverberate even more urgently today as we learn to oreado … Crafted and edited with care, Worth Books set the standard for quality and give you the tools you need to be a well-informed reader. Goodreads Members' Most Anticipated Spring Books. The Gene Quotes Showing 1-30 of 305. CD-Audio US$37.34. The Gene: An Intimate History. Amazon Price. But woven through The Gene, like a red line, is also an intimate history-the story of Mukherjee's own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. /i/. This short summary and analysis of The Gene by Siddhartha Mukherjee includes: Histo But it is more illuminating to write the history of technology through transitions: linear motion to circular motion; visual space to subvisual space; motion on land to motion on air; physical connectivity to virtual connectivity.”, “Our ability to read out this sequence of our own genome has the makings of a philosophical paradox. “McKusick's belief in this paradigm-the focus on disability rather than abnormalcy-was actualized in the treatment of patients in his clinic. Now imagine an ancient tribe of two hundred women, each of whom bears one child. Just a moment while we sign you in to your Goodreads account. 'the gene an intimate history gene siddhartha mukherjee May 31st, 2020 - the gene an intimate history the gene an intimate history siddhartha mukherjee s follow up to the bestselling pulitzer winning the emperor of all maladies is the story of the The exclusively female origin of all the mitochondria in an embryo has an important consequence. The laws of nature still mark the outer boundaries of permissibility - but life, in all its idiosyncratic, mad weirdness, flourishes by reading between the lines.”, “Three profoundly destabilizing scientific ideas ricochet through the twentieth century, trisecting it into three unequal parts: the atom, the byte, the gene.”, “History repeats itself, in part because the genome repeats itself. tags: history , nonfiction , science. by Worth Books. Quotes By Siddhartha Mukherjee. “Freaks become norms, and norms become extinct. The gene an intimate history pdf This article needs additional quotes to verify. The main characters of this science, non fiction story are , . If the child happens to be a daughter, the woman dutifully passes her mitochondria to the next generation, and, through her daughter’s daughter, to a third generation. There is an exquisite precision in that mad scheme. Depraved”, “Illness might progressively vanish so might identity. Error rating book. This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. Start by marking “Summary and Analysis of The Gene: An Intimate History: Based on the Book by Siddhartha Mukherjee” as Want to Read: Error rating book. Publisher: Simon & Schuster Export, 2016. Infirmities might disappear, but so might vulnerability. Hardcover – Illustrated, May 17 2016. by Siddhartha Mukherjee (Author) 4.7 out of 5 stars 1,535 ratings. But they must also leave exactly enough room for the vagaries of chance to stick. The genome is only a mirror for the breadth or narrowness of human imagination.”, “Memories sharpen the past; it is reality that decays.”, “The point is this: if you cannot separate the phenotype of mental illness from creative impulses, then you cannot separate the genotype of mental illness and creative impulse.”, “Like musicians, like mathematicians—like elite athletes—scientists peak early and dwindle fast. And the genome repeats itself, in part because history does. Want to Read. It is quite the opposite: it is the inference of a person's characteristics from their race. Mitochondria, recall, carry a small, independent genome that resides within the mitochondrion itself—not in the cell’s nucleus, where the twenty-three pairs of chromosomes (and the 21,000-odd human genes) can be found. I will read The Gene. But the cellular material of the embryo comes exclusively from the egg; the sperm is no more than a glorified delivery vehicle for male DNA—a genome equipped with a hyperactive tail. The Gene is the story of one of the most powerful and dangerous ideas in our history … Welcome back. To produce that single illuminating experiment, a thousand nonilluminating experiments have to be sent into the trash; it is battle between nature and nerve. The book was published in multiple languages including English, consists of 592 pages and is available in Hardcover format. That ghastly distinction falls on India and China, where more than 10 million female children are missing from adulthood because of infanticide, abortion, and neglect of female children. Welcome back. This brief overview of The Gene tells you what you need to know—before or after you read Siddhartha Mukherjee’s book. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. “The Gene: An Intimate History” is a major new four-hour documentary from Ken Burns and Barak Goodman, adapted from the award-winning book of the same name by Dr. Siddhartha Mukherjee. Hindu philosophers have long described the experience of "being" as a web - jaal. Amazon Kindle Edition. December 13th 2016 Chicago / Turabian - Humanities Citation (style guide) Mukherjee, Siddhartha, The Gene: An Intimate History. Another half will dead-end into male children in the second generation, and so forth. 4.37 avg rating • (25,044 ratings by Goodreads) Softcover ISBN 10: 150115012X ISBN 13: 9781501150128. Speaking at the Sorbonne in 1975, the cultural historian Michel Foucault once proposed that “a technology of abnormal individuals appears precisely when a regular network of knowledge and power has been established.” Foucault was thinking about a “regular network” of humans. Grief might be diminished, but so might tenderness. And human history has, in turn, selected genomes that carry these impulses, ambitions, fantasies, and desires. It is far too much to ask ourselves to escape the orbit of this logic, but recognizing its inherent circularity, and being skeptical of its overreach, might protect the week from the will of the strong, and the 'mutant' from being annihilated by the 'normal'.”, “It is tempting to write the history of technology through products: the wheel; the microscope; the airplane; the Internet. 57 likes. The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function.The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856 where a … The gene is “one of the most powerful and dangerous ideas in the history of science,” argues Siddhartha Mukherjee in The Gene: An Intimate History. The gene an intimate history pdf download, Mississippi blood a novel natchez burning, PDF | The Gene: An Intimate History by Siddhartha Mukherjee, first published in , is a … —John Sulston Scholars”, “Consider the genesis of a single-celled embryo produced by the fertilization of an egg by a sperm. “Freaks become norms, and norms become extinct. The impulses, ambitions, fantasies, and desires that drive human history are, at least in part, encoded in the human genome. Aside from proteins, ribosomes, nutrients, and membranes, the egg also supplies the embryo with specialized structures called mitochondria. “All is a process of adjustment and readjustment, or else eventual failure.” By”, “If the history of the last century taught us the dangers of empowering governments to determine genetic “fitness” (i.e., which person fits within the triangle, and who lives outside it), then the question that confronts our current era is what happens when this power devolves to the individual. Non-sources of materials can be challenged and removed. By the end of several generations, all the descendants of the tribe, male or female, might track their mitochondrial ancestry to just a few women. The Gene: An Intimate History is an epic story of how we have come to understand some of the fundamental building blocks of life on earth. Ken Burns presents THE GENE: AN INTIMATE HISTORY, a two-part, four-hour documentary based on Pulitzer Prize-winning author Dr. Siddhartha Mukherjee’s book … "The Gene: An Intimate History" is a major new four-hour documentary from Ken Burns and Barak Goodman, adapted from the award-winning book of the same name by Dr. Siddhartha Mukherjee. We do not know what she looked like, although her closest modern-day relatives are women of the San tribe from Botswana or Namibia. When you decide to test for ‘future risk,’ you are also, inevitably, asking yourself, what kind of future am I willing to risk?” Three case studies illustrate the power and the peril of using genes to predict “future risk.”, “There is no permanent status quo in nature,” Muller later wrote. The Gene: An Intimate History weaves together science, history & personal stories for a historical biography of the human genome, while also exploring breakthroughs for diagnosis & treatment of genetic diseases & the complex ethical questions they raise. The Gene: An Intimate History is an epic story of how we have come to understand some of the fundamental building blocks of life on earth. Dobzhansky”, “The universe seeks equilibriums; it prefers to disperse energy, disrupt organization, and maximize chaos. Our genes do not keep spitting out stereotypical responses to idiosyncratic environments: if they did, we too would devolve into windup automatons. Informative and a good summary of the book it appears. Can an intelligent being comprehend the instructions to make itself? The question is not, can you, given an individual's skin color, hair texture, or language, infer something about their ancestry or origin. Chicago / Turabian - Author Date Citation (style guide) Mukherjee, Siddhartha. A history of the study of genes and how research could affect the future of humanity Goodreads reviews for The Gene: An Intimate History USA Today's Best-Selling Books List This specific ISBN edition is currently not available. All humans—male or female—must have inherited their mitochondria from their mothers, who inherited their mitochondria from their mothers, and so forth, in an unbroken line of female ancestry stretching indefinitely into the past. The genetic material of this embryo comes from two sources: paternal genes (from sperm) and maternal genes (from eggs). About the Book: The Gene: An Intimate History Nominated for Royal Society Science Book Prize Nominee (2016), Wellcome Book Prize Nominee (2017), PEN/E.O. Genes form the threads of the web; the detritus that sticks is what transforms every individual web into a being. But woven through The Gene, like a red line, is also an intimate history - the story of Mukherjee's own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. It is quite another thing to imagine altering identity or sexuality or behavior by altering genes.”, “The problem with racial discrimination, though, is not the inference of a person's race from their genetic characteristics. Spring is Mother Nature’s way of saying, “Oof–let’s try this again.” The last 12 months have been, well, challenging is the polite term.... To see what your friends thought of this book, Summary and Analysis of The Gene: An Intimate History: Based on the Book by Siddhartha Mukherjee. In the prologue, author Siddhartha Mukherjee writes about his family history of mental illness and connects this personal story to his larger questions about the nature of genes, genetics, and heredity. Ken Burns presents THE GENE: AN INTIMATE HISTORY will premiere on DPTV on Tuesday, April 7 and April 14, as a two-part, four hour limited series developed with Ken Burns, Barak Goodman, and Dr. Siddhardtha Mukherjee, the Pulitzer Prize-winning author of the book upon which the documentary is based. The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). The goal was not to restore "normalcy"-but vitality, joy, and function. Patients with dwarfism, for instance, were treated by an interdisciplinary team of genetic counselors, neurologists, orthopedic surgeons, nurses, and psychiatrists trained to focus on specific disabilities of persons with short stature. 'the gene an intimate history May 30th, 2020 - the gene an intimate history is a book written by siddhartha mukherjee an indian born american physician and oncologist it was published on 17 may 2016 by scribner the book chronicles the history of the gene and genetic research all the way from aristotle to crick watson and franklin and then the Refresh and try again.
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